22. What is an Epidermal Nerve Fiber Density Biopsy?

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An epidermal nerve fiber density biopsy, also called an intraepidermal nerve fiber density biopsy or a nerve density skin biopsy, is a test that is performed by a physician to determine if you have a small fiber neuropathy.  It is a simple relatively painless skin biopsy.  The biopsy is sent to a pathology lab where it is treated with a special stain and the small nerve fibers in the skin are counted.  If the density of the small nerve fibers in the skin is less than normal the diagnosis of small fiber neuropathy may be made. 

Questions and Answers About Peripheral Neuropathy ​

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